The takeaway
Spyre Therapeutics Inc. shows a pronounced seasonal pattern over 10 years of data — strongest in August (+11.6%) and softest in April (−5.0%).
Right now
In July, the stock has fallen 40% of years, averaging −1.7%, roughly 3.9 pts behind the S&P 500.
The full picture
Spyre Therapeutics Inc.'s most dependable month has been August, higher in 9 of 10 years; April has been its least reliable, up just 10% of the time.
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Month by month
The stock's clearest edge over the S&P 500 lands in June (+11.5 pts); it has trailed the market most in May (−7.1 pts).
“vs S&P” is Spyre Therapeutics Inc.’s average for a month minus the S&P 500’s average for that same month — isolating Spyre Therapeutics Inc.’s own seasonal edge from broad market drift.
Reality check
Over the last 5 years, August has closed higher 100% of the time versus 90% across the last 10 years — the pattern is weakening.
Figures are the typical (median) August return and how often it rose — the last 5 years versus the last 10(the heatmap’s default window). This verdict stays anchored to that 10-year window even if you zoom the chart, so it never disagrees with the badges above.
In plain English
Strip the year back and a single month does the heavy lifting: August, up in 9 of 10 Augusts while the other eleven tend to blur together.
Its average (+11.6%) and median (+12.3%) land within a hair of each other — the tell of steady, year-after-year gains rather than one outlier doing the work. It is among its calmest months, too, its returns swinging least from year to year (a 12.7% spread), and even its worst August in 10 years lost only 13.3% — the gentlest downside anywhere on its calendar. Crucially, the gain is the stock's own rather than a rising tide's: August has cleared the S&P 500 by +11.2 points above the index. That consistency sets it apart from the field, where the average stock manages August only about 52% of the time.
Only September comes anywhere near it for reliability. At the other end of the calendar, April has been the soft spot — the weakest of 6 months that average a loss (−5.0%), and the edge isn't year-round — the stock has trailed the S&P 500 in May, April, and December. Its roughest month on record was a −66.3% June in 2022 — a reminder of how hard even a seasonal name can fall.
August has now closed higher 6 years running. The pattern has softened of late, August's last five years slipping below its longer-run record.
The takeaway is less about when to buy than what to expect: August aside, the stock's months offer little reliable tilt. With returns that swing hard year to year, the signal is best held loosely.
Short answers on the stock's best month (August), its worst (April), and whether it really trades seasonally.
Yes, to a pronounced degree. Since 2016 its best month (August, +11.6%) has run well ahead of its worst (April, −5.0%) — the heatmap above shows how steady that gap has been year to year.
August has been the strongest, averaging +11.6% and closing higher in 9 of 10 years since 2016.
It's the weakest, averaging −5.0% — historically a soft spot, though it still varies from year to year.
Explore
These names have the strongest July track records on record — a starting point for comparison.
Before you trade